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pinterest. facebook. How To Treat Diabetic Diarrhea? I have a problem that I never see addressed. I've had type 1 diabetes for 36 years and been diagnosed as having diabetic diarrhea. Numerous … Metformin is the most widely prescribed drug for patients with type 2 diabetes mellitus and the first-line pharmacological option as supported by multiple international guidelines, yet a rather large proportion of patients cannot tolerate metformin in adequate amounts because of its associated gastrointestinal (GI) adverse events (AEs). Always take the Metformin right after a meal.

Because metformin is an insulin-sparing drug (insulin sensitizer), its use does not increase body weight nor provoke hypoglycemia, Mechanism of action. The possible mechanisms of action of metformin is by reduction of hepatic glucose production through activation of the …

The most significant adverse drug reactions of metformin are lactic acidosis, allergies, hypoglycemia, vitamin B12 Metformin has been used in Europe and Canada for more than 50 years (since 1957), although the US Food and Drug Administration (FDA) only approved it in December 1994. Its mechanism of action is poorly understood.

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Digestive disorders (diarrhoea, vomiting) represent the most common metformin side-effects (around 30%) with this first-line drug treatment for type 2 diabetes. In healthy individuals, metformin affects glucose, vitamin B12 and the digestive uptake of bile salts. In the colon, it acts locally by modifying glucose cell metabolism.

Patients with type 2 diabetes who are taking metformin and experience diarrhea deserve a drug-free interval before undergoing expensive and uncomfortable diagnostic tests, even when the dosage has been stable over a long period. Metformin Diarrhea Mechanism .
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13 Sep 2019 Metformin, the first-line drug in the treatment of type 2 diabetes (T2DM), may cause dose dependent undesirable side-effects like diarrhea, The mechanism of the gastrointestinal intolerance in patients treated with met

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